Targeted Sarcoplasmic Reticulum Ca2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart
MJ Cutler, X Wan, BN Plummer, H Liu, I Deschenes… - Circulation, 2012 - Am Heart Assoc
… to cardiac alternans. Therefore, we hypothesized … restoring deficient SERCA2a by
gene transfer will significantly reduce arrhythmogenic cardiac alternans in the failing heart…
gene transfer will significantly reduce arrhythmogenic cardiac alternans in the failing heart…
Sarcoplasmic reticulum Ca2+ ATPase as a therapeutic target for heart failure
L Lipskaia, ER Chemaly, L Hadri… - … on biological therapy, 2010 - Taylor & Francis
… heart failure gene therapy: i) new insights on calcium regulation by SERCA2a; ii) SERCA2a
as a gene therapy target … is a major predictor of electrical instability and arrhythmias. Hence, …
as a gene therapy target … is a major predictor of electrical instability and arrhythmias. Hence, …
SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure
AR Lyon, ML Bannister, T Collins… - Circulation …, 2011 - Am Heart Assoc
… vivo with provocation protocols aimed at producing reentry … of sarcoplasmic reticulum
calcium ATPase 2a (SERCA2a) … by luminal Ca 2+ may also have been altered to a more stable …
calcium ATPase 2a (SERCA2a) … by luminal Ca 2+ may also have been altered to a more stable …
Altered sarcoplasmic reticulum calcium cycling—targets for heart failure therapy
C Kho, A Lee, RJ Hajjar - Nature Reviews Cardiology, 2012 - nature.com
… Restoration of sarcoplasmic reticulum Ca 2+ uptake through activation of sarcoplasmic/endoplasmic
reticulum calcium ATPase 2a … FKBP12.6 also contributes to stabilization of the RyR2 …
reticulum calcium ATPase 2a … FKBP12.6 also contributes to stabilization of the RyR2 …
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases
Y Kawase, RJ Hajjar - Nature Clinical Practice Cardiovascular …, 2008 - nature.com
… lumen of the sarcoplasmic reticulum during muscle relaxation… in failing cardiomyocytes and
have used targeted gene delivery. A … Ca 2+ /calmodulin-dependent protein kinase II, which …
have used targeted gene delivery. A … Ca 2+ /calmodulin-dependent protein kinase II, which …
Gene therapy targeted at calcium handling as an approach to the treatment of heart failure
M Hoshijima - Pharmacology & therapeutics, 2005 - Elsevier
… , reduced calcium loading in cardiac sarcoplasmic reticulum (SR), and … muscle type (2a)
splicing variant of SERCA2 gene is the … RyR stabilization may improve SR calcium load and the …
splicing variant of SERCA2 gene is the … RyR stabilization may improve SR calcium load and the …
[HTML][HTML] Targeting calcium regulators as therapy for heart failure: Focus on the sarcoplasmic reticulum Ca-ATPase pump
C Kho - Frontiers in Cardiovascular Medicine, 2023 - ncbi.nlm.nih.gov
… of heart failure, and gene transfer therapies aimed at restoring … In failing human hearts,
PLN levels remain stable, whereas … positive outcomes in NYHA class II-III HF patients with …
PLN levels remain stable, whereas … positive outcomes in NYHA class II-III HF patients with …
… Gene Therapy in Cardiac Disease (CUPID) A Phase 2 Trial of Intracoronary Gene Therapy of Sarcoplasmic Reticulum Ca2+-ATPase in Patients With Advanced Heart …
M Jessup, B Greenberg, D Mancini, T Cappola… - Circulation, 2011 - Am Heart Assoc
… A first-in-human, phase 1 trial was conducted to restore the … , and implantable cardiac
defibrillators and were on stable (at least … heart failure on the basis of a novel strategy of targeting …
defibrillators and were on stable (at least … heart failure on the basis of a novel strategy of targeting …
Improvement in Survival and Cardiac Metabolism After Gene Transfer of Sarcoplasmic Reticulum Ca2+-ATPase in a Rat Model of Heart Failure
F Del Monte, E Williams, D Lebeche, U Schmidt… - Circulation, 2001 - Am Heart Assoc
… SERCA2a as a therapeutic target. Pharmacological agents that … A stable energetic state in
rat hearts was confirmed from 31 P … in failing compared with sham LVs, as shown in Figure 2A. …
rat hearts was confirmed from 31 P … in failing compared with sham LVs, as shown in Figure 2A. …
Sarcoplasmic reticulum and calcium cycling targeting by gene therapy
JS Hulot, G Senyei, RJ Hajjar - Gene therapy, 2012 - nature.com
… Restoration of contractile function in isolated cardiomyocytes from failing human hearts by
gene transfer of … Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic …
gene transfer of … Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic …